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Technology: Cell&Gene Therapy Disease focus: Type I Diabetes and Multiple Sclerosis Clinical status: Pre-clinical
Altheia Science develops a gene therapy-based approach in Type I diabetes and multiple sclerosis that aims at reverting the root cause of the disease, by ex vivo lentiviral vector-transducing autologous hematopoietic stem and progenitor cells (HSPC) to reconstitute PD-L1 expression. Re-inoculation of modified HPSC should entail the establishment of a correct balance in controlling immune responses, by promoting a tolerogenic effect triggering the PD-1/PD-L1 axis with the result to exhaust auto-reactive T lymphocytes effector capabilities, thus preventing auto-immune reactions against self-antigens. The approach has the potential to be transformative in the management of autoimmune diseases.
Type of investors who funded this startup
- Venture Capital
Incubated or Accelerated
Human health activities